Morning Overview on MSN

Stem-cell edits may program the immune system to make therapeutic proteins

For the roughly 30,000 Americans living with hemophilia and thousands more with rare enzyme deficiencies, treatment often ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
Center for Strategic and International StudiesOpinion

The Infrastructure Trap: What Beijing Has Learned from Moscow’s Playbook in Central Asia

President Xi Jinping’s decision to announce what would become the Belt and Road Initiative in Kazakhstan in 2013 was no ...
eLife

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

HIV-1 envelope glycoprotein (Env), a gp120–gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing ...