Genomics England

Genomic Data Scientist in Rare Disease (we have office locations in Cambridge, Leeds & London)

Job Description We are seeking a passionate and innovative Genomic Data Scientist to join our cutting-edge team.  You will ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
AHA/ASA Journals

Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene …

BACKGROUND: Preeclampsia affects approximately 1 in 10 pregnancies, leading to severe complications and long-term health ...
BMJ Open

Co-exploring how environments shape brain health through a planetary health lens: a photovoice study in Auckland, Aotearoa New Zealand

Objectives Dementia prevention and climate action share a common imperative: safeguarding future generations’ health. Despite ...
British Journal of Ophthalmology

Publicly available multimodal large language models for ocular surface infections: benchmarking against corneal specialists in triage, diagnosis and tr…

Background/aims Ocular surface infections remain a major cause of visual loss worldwide, yet diagnosis often relies on slow ...